Inhalation of sulfuric ether during the removal of a neck tumor on March 30, 1842, marked the first instance of a patient undergoing surgery without experiencing pain. Performed by Crawford Williamson Long in Jefferson, Georgia, this procedure predated the widely publicized public demonstrations of ether anesthesia that would later dominate the mid-nineteenth-century medical discourse.
Early Education and Medical Training
Born in 1815 in Danielsville, Georgia, Long pursued early studies at the University of Georgia, graduating in 1835. He continued his medical education at Transylvania College in Lexington, Kentucky, where he observed surgery under the instruction of Benjamin Dudley. He later transferred to the Perelman School of Medicine at the University of Pennsylvania, earning his M.D. degree in 1839.
Twenty questions, eight minutes on the clock, and a percentile measured against everyone who has taken it. No sign-up.
Take the IQ test →Pioneering Anesthetic Practice
Following a residency in New York, Long established a medical practice in Jefferson in 1841. He observed that sulfuric ether produced physiological effects similar to those documented by Humphry Davy for nitrous oxide. Applying this insight, he performed several successful surgeries, including tumor excisions and amputations, as well as providing anesthesia for childbirth. He did not publish these findings until 1849.
The Priority Controversy
In 1846, William T. G. Morton conducted a public demonstration of ether anesthesia in Boston, which garnered widespread attention. When reports of other claimants, including Charles Jackson and Horace Wells, surfaced, Long began documenting his prior work. Despite providing notarized accounts and petitioning Congress through Senator William Crosby Dawson in 1854, Long failed to secure official recognition for his priority during his lifetime.
Later Years and Legacy
Long relocated his practice to Atlanta in 1850 and eventually to Athens in 1851. During the American Civil War, he served as a surgeon to soldiers. He died of a stroke in 1878 shortly after assisting in a delivery and was interred at Oconee Hill Cemetery. His contribution to anesthesia was later supported by scholar Marion Sims, who provided the first major publication verifying Long’s earlier clinical successes.
Fast facts
- Born: 1815, Danielsville, Georgia
- Died: 1878, Athens, Georgia
- Education: University of Georgia; University of Pennsylvania
- First Ether Surgery: March 30, 1842
- Burial: Oconee Hill Cemetery
- Fields of Work: Physician, Surgeon, Pharmacist
Questions readers ask
Why was Crawford Long not recognized immediately for his discovery?
He delayed publishing his clinical results in a medical journal until 1849, by which time other practitioners had performed and publicized their own demonstrations of ether anesthesia.
What medical procedures did Long use ether for?
He utilized inhaled sulfuric ether primarily for tumor removals, amputations, and as a form of pain management during childbirth.
Achievements
- Fields: medicine
.jpg)


