Nitrous oxide became a medical tool after Horace Wells observed a local clerk injure his legs during a public exhibition of laughing gas in Hartford, Connecticut, in 1844. Realizing the substance could eliminate pain, Wells immediately initiated a self-experiment, having his own wisdom tooth extracted while under the influence to prove the efficacy of the gas.
Background and Early Career
Born on January 21, 1815, in Hartford, Vermont, to Horace and Betsy Heath Wells, he was raised in an affluent family with deep roots in the American Revolution. He received his early education at private schools in New Hampshire and Massachusetts. Following a brief period considering the ministry, he moved to Boston in 1834 for a two-year dental apprenticeship under Dr. N. C. Keep. By 1836, he opened his private practice in Hartford, where he earned a reputation for technical skill, notably designing his own instruments and gold restorations.
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At 23, Wells published An Essay on Teeth, a work that championed preventive care. He argued that consistent brushing could prevent decay and identified sugar as a primary cause of dental degradation. Beyond routine hygiene, he was a strong proponent of preserving primary teeth, advising that they remain in place until natural loss unless they posed significant discomfort. His focus on these early prophylactic measures highlighted his comprehensive view of dental health.
Development of Anesthesia
Wells became increasingly concerned with the intense pain patients endured during tooth extractions. After observing Gardner Quincy Colton’s public demonstration of nitrous oxide at Union Hall on December 10, 1844, he saw an application for the gas in clinical practice. Following his successful self-experiment the next day with his partner John Riggs, he refined the preparation of the gas and treated at least 12 other patients. Though pressured by associates to patent the discovery, he famously refused, maintaining that the relief of pain should remain freely accessible to everyone.
Professional Legacy
Throughout his career in Hartford, Wells instructed several apprentices, including William T. G. Morton, John Mankey Riggs, and C. A. Kingsbury. He maintained a profitable practice that attracted prominent members of society, including Connecticut Governor William W. Ellsworth. He died in New York City on January 24, 1848, and was buried at Cedar Hill Cemetery. His work fundamentally transitioned surgery from a traumatic, involuntary ordeal into a manageable medical procedure.
Fast facts
- Born: January 21, 1815, Hartford, Vermont
- Died: January 24, 1848, New York City
- Citizenship: United States
- Primary Occupation: Dentist
- Key Discovery: Nitrous oxide for surgical anesthesia
- Notable Partner: John Mankey Riggs
- Burial Site: Cedar Hill Cemetery
Questions readers ask
Did Horace Wells patent nitrous oxide?
No, he specifically chose not to patent the discovery, believing that pain relief should be free for all.
What event inspired Wells to use laughing gas?
He observed a clerk at a public exhibition in 1844 sustain physical injuries while under the influence of the gas without experiencing pain.
Achievements
- Fields: dentistry

